HYBRID EVENT: You can participate in person at Orlando, FL, USA or Virtually from your home or work.

International Conference on Gastroenterology

April 20-22, 2023

April 20 -22, 2023 | Orlando, Florida, USA
Gastro 2023

Ishaan Jakhar

Speaker at Gastroenterology 2023 - Ishaan Jakhar
internal medicine specialist, United States
Title : Risk factors for development of severe gastrointestinal dysmotility in patients with systemic sclerosis


Systemic Sclerosis (SSc) is an autoimmune condition of unknown etiology. We aim to investigate incidence, characteristics, and risk factors for gastrointestinal (GI) dysmotility in patients diagnosed with SSc using Cerner HealthFacts, a national longitudinal database representing approximately 69 million patients.
Methods All patients over 18 years of age with SSc were included in our analysis. Incidence of GI dysmotility was identified using ICD coding. Patient characteristics were evaluated as potential risk factors for development of GI dysmotility using multivariable regression built using all variables with p<0.1 on univariable analysis.
Results Overall, 0.4% (58/13,930) of patients with SSc developed GI dysmotility. Mean age was 57.23±15.22 years and 16% (2,228/13,930) were male and 86.1% (11,502/13,930) were female. In terms of race, 70.15% (9,772/13,930) were white and 14.82% (2,064/13,930) were African American. 92.51% (12,886/13,930) received care at an acute care facility and 81.51% (11,354/13,930) received care at an urban facility. The variables which conferred the highest odds of developing GI dysmotility included presence of hepatic comorbidities (OR 2.35), digestive comorbidities (OR 6.75), muscular dystrophy (OR 569.2), and Raynaud (OR 1.98). In our univariable analysis and multivariable regression model with 95% confidence intervals; 4 variables were predictive for GI dysmotility, and no variables were protective against GI dysmotility.
Conclusions In this longitudinal national database study of patient with diagnosed SSc - hepatic, digestive comorbidities, muscular dystrophy, and Raynaud were noted to be associated with high risk of developing GI dysmotility. Careful evaluation and follow up is advised for SSc patients.


Dr. Ishaan Jakhar studied Medicine at the University of Missouri at Kansas City, US, and graduated as B.A/M.D. in 2020. He completed Graduate Certificate in Clinical Research in 2019. He completed TL1 Pre-doctoral Research Grant at WASHU. It is a full-time clinical and translational research experience with didactic course work. He is recipient of Sarah Morrison Medical Research Award University of Missouri- School of Medicine. He is presently working at St. Luke's Hospital, Chesterfield, MO. He has published more than 20 research articles in scientific journals.