GASTRO 2024_ Event Postponement

This is to inform that due to some circumstances beyond the organizer control, “2nd Edition of International Conference on Gastroenterology” (Gastro 2024) during October 21-23, 2024 at Baltimore, MD, USA has been postponed. The updated dates and venue will be displayed shortly.

Your registration can be transferred to the next edition, if you have already confirmed your participation at the event.

For further details, please contact us at gastroenterology@magnusconference.com or call + 1 (702) 988-2320.

HYBRID EVENT: You can participate in person at Baltimore, MD, USA or Virtually from your home or work.

2nd Edition of International Conference on Gastroenterology

October 21-23, 2024, Baltimore, Maryland, USA

October 21 -23, 2024 | Baltimore, MD, USA
Gastro 2024

The mechanism of associating liver partition and portal vein ligation: A systematic review

Speaker at GI Conferences - Junwei Zhang
Junwei Zhang
Peking Union Medical College Hospital, China
Title : The mechanism of associating liver partition and portal vein ligation: A systematic review

Abstract:

Background:
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was widely used in clinic. The mechanism of ALPPS need to be fully illustrated.

Methods:
The present systematic review aimed to examine existing data on the mechanism of ALPPS. Electronic databases, including PubMed, Web of Science and Embase, were systemically searched to retrieve articles on ALPPS. Meanwhile, additional articles were identified manually. The mechanisms of ALPPS, including the animal model, histological changes, surgical method, signaling pathway influence of abnormal liver and oncological results, were analyzed.

Results:
After screening, we included 66 articles. including 53 studies on animals and 13 studies on humans. The rat model of ALPPS was mostly used, and the proliferation of hepatocytes was thought to be immature. However, the origin of hepatocytes is still not clear. The JNK1-IHH axis is a mechanism unique to ALPPS surgery, while mitochondrial function, the hypoxia pathway and inflammatory factors also play an important role in liver regeneration. NAFLD and cirrhosis were thought to be negatively associated with liver growth of ALPPS, but the exact mechanism was still not clear. The role of ALPPS in inducing the growth of tumors was contradictory.

Conclusions:
This review concluded that the JNK1-IHH axis was a mechanism unique to ALPPS surgery, and the origin of hepatocytes in ALPPS, the influence of abnormal liver for ALPPS and oncological results were still not clear. Future studies should focus on these directions and try to explore drugs to enhance liver regeneration of ALPPS without stimulating the growth of tumors.

Audience Take Away:

  • JNK1-IHH axis was a mechanism unique to ALPPS surgery, and the origin of hepatocytes in ALPPS.

  • Future studies should focus on these directions and try to explore drugs to enhance liver regeneration of ALPPS without stimulating the growth of tumors.

Biography:

Zhang Junwei is a clinical doctoral candidate in liver surgery of Peking Union Medical College Hospital. He also participated in the establishment of the ALPPS database of Peking Union Medical College Hospital, the liver cancer surgery specimen bank, and the cohort study of advanced liver cancer. As the first author, he published 17 SCI papers related to clinic. The cumulative total impact factor exceeds 200 points.

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