The population in Israel is composed of diverse communities: Jews, Arabs, and immigrant groups from various countries, including communities from Yemen, Ethiopia, Morocco, the former Soviet Union, and a long-standing population. Numerous medical studies have examined specific [....] » Read More
Sickle cell disease (SCD) is a common inherited hematological disorder in Saudi Arabia, and hepatic involvement is an important but frequently underestimated component of its multisystem burden. This presentation reviews the spectrum of sickle cell liver disease (SCLD), highlight [....] » Read More
The Chernobyl nuclear accident in 26 April 1986 marked a turning point in both the history of energy production and our understanding of the relationship between human technology and the life. J.R. Oppenheimer evoked the famous words from the Hindu scrip [....] » Read More
This keynote examines the bidirectional gut-brain axis and its clinical relevance for gastroenterology practice, emphasizing that psychological and emotional states influence gastrointestinal symptoms through real, measurable physiology-and that GI symptoms can, in turn, shape mo [....] » Read More
Background: Ulcerative colitis (UC) is associated with dysbiosis of the gut microbiota, reduced short-chain fatty acid (SCFA) production, and a pro-inflammatory cytokine profile. Fermented foods contain prebiotic and probiotic elements which may correct these deficits but the s [....] » Read More
Background: Surgical site infection is one of the significant complications in post-operative patients. Method of preoperative hair removal is also considered as one of the risk factors for causing SSI. Razor blade, depilatory cream, clippers are used for hair removal. The o [....] » Read More
A 67-year-old man presenting repeatedly with fever, diarrhoea, and progressive thoracic back pain following recent travel. Blood cultures confirmed Salmonella Java bacteraemia. Initial Computed Tomography (CT) was unremarkable. Due to persistent symptoms, repeat CT angiography de [....] » Read More
Introduction: Infliximab therapy in Inflammatory Bowel Disease is associated with rare but serious neurological complications including central and peripheral demyelination, neuropathy, optic neuritis, seizures and encephalomyelitis. These neurological events have not yet be [....] » Read More
Background: Cameron lesions — linear erosions or ulcerations at the diaphragmatic pinch within a hiatal hernia (HH) — are an under-recognized cause of occult gastrointestinal bleeding and chronic iron-deficiency anemia. They are classically associated with large HH, b [....] » Read More
Background: Postoperative endoscopic assessment of the fundoplication wrap remains poorly standardized. Single-parameter classifications such as the Hill grade of the gastroesophageal flap valve, and Mittal-type descriptive systems, have been associated with substantial inter-obs [....] » Read More
Bradycardia in the setting of abdominal pathology is an uncommon clinical finding. Cope’s sign - reflex bradycardia associated with acute cholecystitis (or cardio-biliary reflex) - is a rare but documented occurrence. Recognizing this atypical presentation is critical to av [....] » Read More
The mammalian gut harbors trillions of commensal bacteria that interact with their hosts through various bioactive molecules. However, the mutualistic strategies that hosts evolve to benefit from these symbiotic relationships are largely unexplored. Here we report that mous [....] » Read More
Background: The clinical heterogeneity of metabolic dysfunction-associated steatotic liver disease (MASLD/MAFLD) necessitates precise phenotyping. Conventional markers like body mass index (BMI) fail to distinguish between benign fat accumulation and progressive tissue injury. Th [....] » Read More
Parity is associated with GS only in younger mothers. High estrogen levels, mainly in the last trimester, increases cholesterol saturation of bile and high progesterone levels during all P reduce gallbladder contractility, both phenomenon may help sludge and GS precipitation.&nbs [....] » Read More
AI is so inclusive that it stands to radically alter the employment landscape within medicine. Entire subspecialities will be cannibalized or fragmented into smaller entities. Physicians are both providers and venders of medical services. The services rendere [....] » Read More
Background: Laparoscopic D2 radical distal gastrectomy is a standard treatment for distal gastric cancer. Single-Incision Laparoscopic Surgery (SILS) offers potential advantages in cosmetic outcomes and recovery, but its technical complexity limits widespread adoption. We indepen [....] » Read More
Introduction: The most common bile duct disease in infants is biliary atresia (BA), which typically requires prompt surgical treatment for the best results, mostly pediatric liver transplantation. Globally, BA has an approximate frequency of 5 to 10 per 100,000 births. The study [....] » Read More
Liver related cancer and cirrhosis mortality rates have been reduced globally by the Hepatitis B vaccine however decay still happens. We aimed at determining the prevalence of breakthrough HBV infections (Exposure, Acute and chronic infections) and the prevalence of protective le [....] » Read More
The human gut microbiota constitutes a dynamic and densely populated ecosystem of over 1013 microorganisms whose compositional and functional integrity is essential for nutrient metabolism, epithelial barrier maintenance, immune regulation, and prevention of chronic non-comm [....] » Read More
The human gut microbiota constitutes a dynamic and densely populated ecosystem of over 1013 microorganisms whose compositional and functional integrity is essential for nutrient metabolism, epithelial barrier maintenance, immune regulation, and prevention of chronic non-comm [....] » Read More
Background: The coexistence of hereditary spherocytosis, focal segmental glomerulosclerosis (FSGS), and ulcerative colitis is exceedingly rare and poses significant diagnostic and therapeutic challenges. Case Presentation: This manuscript describes an exceptionally rare cli [....] » Read More
Title : Early and late evaluation of esophageal mucosectomy in surgical treatment of advanced esophageal achalasia
Jose Luis Braga De Aquino, Pontifical Catholic University of Campinas, Brazil
Endoscopic and/or laparoscopic myotomy has shown positive results in non-advanced esophageal achalasia due to the development of this surgical technique currently. For the most advanced stages of the disease, esophagectomy seems to be the most indicated procedure due to the invol [....] » Read More
Title : How epigastric impedance would radically change gastric medicine
John Andrew Sutton, Invention City, United States
Epigastric impedance monitors measure liquid gastric emptying and motility non-invasively. Validated by several PhDs and 25 published papers it detected gastric delay whenever expected, plus the stimulant effect of prokinetics and reduced motility after opiates. Practical, due to [....] » Read More
Title : Nanoemulsions as a strategy to enhance gastrointestinal bioavailability and bioactivity of lipid based nutraceuticals
Pubali Dhar, University of Calcutta, India
Water-immiscible lipophilic bioactive compounds can be efficiently dispersed as colloidal droplets within an aqueous matrix in oil-in-water emulsions. This property has drawn considerable attention to nanoemulsions as promising nanodelivery systems, particularly for enhancing the [....] » Read More
Title : Chronic hepatitis of trematode etiology: Innovative technologies of intraduodenal therapy and quantum-hydrogen liver regeneration
Ashot Khachatryan, International Network of Hydrogen Medicine Clinics, Armenia
Modern international hepatology focuses predominantly on the therapy of viral hepatitis, frequently ignoring concomitant pathologies that provoke, sustain, and exacerbate chronic liver inflammation. Our 30-year clinical experience proves that chronic parasitic infestations are a [....] » Read More
Title : AI-supported autonomous ingestible micro-robotic endoscope with wired high-speed communication for total gastrointestinal exploration and therapy
Hidetoshi Ohta, Sapporo Orthopaedics and Cardiovascular Hospital, Japan
Background and Aims: Artificial intelligence and robotic technologies are rapidly advancing; however, their integration into gastrointestinal endoscopy remains limited and has not yet fully met clinical demands. We are developing a novel ingestible micro-robotic endoscope capable [....] » Read More
Title : Pitfalls in colonoscopy: A rare endoscopic never event identified through histopathological discordance
Rajan Panacer, University Hospitals Birmingham, United Kingdom
Introduction: Colonoscopy is a routinely used diagnostic and therapeutic tool and is considered the gold standard investigation for assessment of colorectal pathology. Whilst colonoscopy can lead to rare but serious complications, incorrect vaginal intubation during these ar [....] » Read More
Title : Trends in compliance with the BSG acute upper gastrointestinal bleeding care bundle at a district general hospital: A four-cycle retrospective audit (2020-2025)
Moses G Ogundipe, University of Buckingham Medical School, United Kingdom
Introduction: Acute Upper Gastrointestinal Bleeding (AUGIB) is a common medical emergency with a 30-day mortality of up to 10%. The British Society of Gastroenterology (BSG) AUGIB consensus care bundle standardises management across six domains: Recognition, Resuscitation, R [....] » Read More
Title : Trends in compliance with the BSG acute upper gastrointestinal bleeding care bundle at a district general hospital: A four-cycle retrospective audit (2020-2025)
Shahd Elhakim, University of Buckingham Medical School, United Kingdom
Introduction: Acute Upper Gastrointestinal Bleeding (AUGIB) is a common medical emergency with a 30-day mortality of up to 10%. The British Society of Gastroenterology (BSG) AUGIB consensus care bundle standardises management across six domains: Recognition, Resuscitation, R [....] » Read More
Title : Iso-osmo-resistivity could explain mechanisms of digestion and absorption
John Andrew Sutton, Invention City, United States
Research into suitable meals for epigastric impedance found that lipid meals like ones containing double cream are highly resistant to electricity while proteins are conductive and carbohydrates are broadly neutral. The finding provoked the question: “Is this the basis by w [....] » Read More
Title : Early and late evaluation of palliative surgical treatment with isoperistaltic gastric tube associated with chemoradiation in advanced esophageal cancer
Jose Luis Braga De Aquino, Pontifical Catholic University of Campinas, Brazil
Although malignant neoplasms of the esophagus remain a very common disease, their diagnosis might often come late. This issue combined with excessive weight loss due to dysphagia and the association with cardiopulmonary diseases resulting from excessive tobacco use, makes patient [....] » Read More
Title : Refractory gastroparesis: A case highlighting severe gastric motility dysfunction and innovative outpatient management
Aysel Ibrahimli, King’s College Hospital NHS Foundation Trust, United Kingdom
Gastroparesis is a gastrointestinal motility disorder characterized by delayed gastric emptying without mechanical obstruction. Diabetes mellitus is a common cause, with chronic hyperglycemia leading to autonomic neuropathy and impaired gastric motor function. Patients often pr [....] » Read More
Title : Mimicking polycystic liver disease: A case report of innumerable cystic hepatic metastases from a pancreatic neuroendocrine tumour and diagnostic role of endoscopic ultrasound
Rida Abbasi, Manchester University NHS Foundation Trust, United Kingdom
Pancreatic neuroendocrine tumours (PNETs) are rare neoplasms, accounting for approximately 1–2% of all pancreatic malignancies. Their clinical and radiological presentation can be highly variable, particularly in non-functioning tumours. Cystic hepatic metastases are an unc [....] » Read More
Title : Safety and feasibility of conscious sedation for EUS-directed transgastric ERCP (EDGE) in post-Roux-en-Y gastric bypass patients: First UK multicentre experience
Khaled Jbarah, Manchester University NHS Foundation Trust, United Kingdom
Background and Aims: EDGE has transformed biliary access in post-Roux-en-Y gastric bypass (RYGB) patients, yet almost all published series describe procedures under general anaesthesia due to perceived aspiration risk and procedural tolerance. Where theatre and anaesthetic capaci [....] » Read More
Title : Immune checkpoint inhibitor-related cholangitis: A single-centre retrospective case series and management outcomes
Ahmed Elshafey, Leeds University Teaching Hospitals, United Kingdom
Background: Since immune checkpoint inhibitors (ICIs) have been introduced for over a decade, a massive improvement in cancer survival rate (median 7.8 to 19.0 months) has occurred but can precipitate immune-related adverse events across organ systems. Immune checkpoint inhibit [....] » Read More
Title : Real world outcomes in fecal incontinence care: Effects of social determinants of health, hormonal therapy, dyssynergic defecation, and treatment engagement
Neha V Patel, UT Southwestern Medical Center, United States
Background & Aims: Fecal incontinence (FI) is a common and debilitating pelvic floor disorder that disproportionately affects women and frequently coexists with other anorectal dysfunctions. Although dyssynergic defecation (DD) is traditionally associated with constipation, i [....] » Read More
Title : Early versus delayed enteral feeding in acute pancreatitis: A literature review
Radhika Patel, Croydon Health Trust, United Kingdom
Background: Acute pancreatitis is a common cause of hospital admission and is associated with significant morbidity and healthcare burden. Traditional management strategies often involved prolonged periods of nil by mouth; however, increasing evidence suggests that early entera [....] » Read More
Title : Integrative medicine for disorders of gut-brain interaction: Evidence-based approaches in irritable bowel syndrome
Neha V Patel, UT Southwestern Medical Center, United States
Disorders of gut-brain interaction (DGBIs), including irritable bowel syndrome (IBS), are among the most prevalent gastrointestinal conditions and are characterized by complex interactions between the enteric nervous system, central nervous system, gut microbiome, immune pathways [....] » Read More
Title : Accuracy of endoscopic ultrasound for tumour and nodal staging in gastro-oesophageal cancer: A single-centre study comparing endoscopic ultrasound with histopathology
Mario Saucedo Padilla, University of Liverpool, United Kingdom
Background: Accurate locoregional staging is essential in gastro-oesophageal cancer to guide treatment selection. Endoscopic ultrasound provides high-resolution assessment of tumour depth and regional lymph nodes, but real-world performance varies. Aim: To evaluate the diagnos [....] » Read More