Title : Intersecting haematologic, renal, and gastrointestinal disease: Hereditary spherocytosis with primary FSGS and ulcerative colitis: A case report
Abstract:
Background: The coexistence of hereditary spherocytosis, focal segmental glomerulosclerosis (FSGS), and ulcerative colitis is exceedingly rare and poses significant diagnostic and therapeutic challenges.
Case Presentation: This manuscript describes an exceptionally rare clinical constellation, hereditary spherocytosis, primary focal segmental glomerulosclerosis, and ulcerative colitis occurring in an 18-year-old white English girl. Her disease course was complicated by intolerance to systemic corticosteroids, recurrent fluid overload, and acute kidney injury. During immunosuppressive therapy with tacrolimus, she developed severe gastrointestinal symptoms, and endoscopic and histological evaluation confirmed ulcerative colitis. Management required coordinated multidisciplinary care involving nephrology, gastroenterology, and haematology. We believe this case provides clinically valuable insights into multisystem immune dysregulation, diagnostic complexity, and the challenges of coordinating care across specialties. The report adheres fully to CARE case report guidelines, and written consent for publication has been obtained. The work is original, has not been submitted elsewhere, and contains no conflicts of interest.
Conclusion: Given the intersection of haematology, nephrology, and gastroenterology, we believe the manuscript would be of particular interest to clinicians managing complex inflammatory and renal disease in young adult populations.
