The Chernobyl nuclear accident in 26 April 1986 marked a turning point in both the history of energy production and our understanding of the relationship between human technology and the life. J.R. Oppenheimer evoked the famous words from the Hindu scrip [....] » Read More
Water-immiscible lipophilic bioactive compounds can be efficiently dispersed as colloidal droplets within an aqueous matrix in oil-in-water emulsions. This property has drawn considerable attention to nanoemulsions as promising nanodelivery systems, particularly for enhancing the [....] » Read More
Gastroparesis is a gastrointestinal motility disorder characterized by delayed gastric emptying without mechanical obstruction. Diabetes mellitus is a common cause, with chronic hyperglycemia leading to autonomic neuropathy and impaired gastric motor function. Patients often pr [....] » Read More
Background and Aims: EDGE has transformed biliary access in post-Roux-en-Y gastric bypass (RYGB) patients, yet almost all published series describe procedures under general anaesthesia due to perceived aspiration risk and procedural tolerance. Where theatre and anaesthetic capaci [....] » Read More
Background: Endoscopic full-thickness resection (EFTR) has emerged as an advanced minimally invasive technique capable of achieving en bloc resection of gastric wall lesions while preserving organ integrity. However, its role in early gastric cancer (EGC), particularly in patient [....] » Read More
Background & Aims: Incomplete radiofrequency ablation (iRFA) in hepatocellular carcinoma (HCC) leaves residual tumors within an immunosuppressive microenvironment. Plasmacytoid dendritic cells (pDCs) and invariant natural killer T (iNKT) cells are critical for anti-tumor [....] » Read More
Background and Aims: Metabolic Dysfunctional-Associated Steatotic Liver Disease (MASLD) emerges as a hepatic manifestation, characterised by excessive lipid accumulation and other intertwined metabolic risk factors such as obesity and type 2 diabetes. Recent evidence highlights a [....] » Read More
Background and objective: Celiac disease is a major public health problem, and alterations in the gut microbiota appear to play an important role in its development. The main objective of this study, conducted in a Moroccan population, was to examine the gut microbiota in patient [....] » Read More
Introduction: Hepatitis B viral (HBV) infection is endemic in Africa with an estimated 82 million people being chronically infected. Liver biopsy remains the goal standard means of assessment of necro-inflammation and fibrosis in the liver. However, its various drawbacks as well [....] » Read More
Objective: To assess whether Histoacryl injection with clips is superior to Histoacryl injection alone in terms efficacy and safety. Methods: Patients with gastric varices who were admitted to our Department and received Histoacryl injection or Histoacryl injection with cli [....] » Read More
Objectives: This study aimed to clarify GAA metabolism changes in macrophages during AP, explore its mechanism in alleviating pancreatic necrosis via regulating efferocytosis, and identify novel therapeutic targets. Materials and Methods: Using single-cell and transcriptomic seq [....] » Read More
Introduction: Current prescribing guidelines restrict Lenvatinib to patients with serum bilirubin ≤3 mg/dL, a threshold derived from pharmacokinetic data in hepatocellular dysfunction. This restriction does not distinguish between hepatocellular decompensation and tumou [....] » Read More
Introduction: Infliximab therapy in Inflammatory Bowel Disease is associated with rare but serious neurological complications including central and peripheral demyelination, neuropathy, optic neuritis, seizures and encephalomyelitis. These neurological events have not yet be [....] » Read More
Background: Accurate locoregional staging is essential in gastro-oesophageal cancer to guide treatment selection. Endoscopic ultrasound provides high-resolution assessment of tumour depth and regional lymph nodes, but real-world performance varies. Aim: To evaluate the diagnos [....] » Read More
Introduction: Metabolic dysfunction–associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disease worldwide, affecting approximately 25-30% of the adult population. As the hepatic manifestation of systemic metabolic dysfunction, MASLD is str [....] » Read More
Background: Functional constipation is one of the most common gastrointestinal disorders in children and is frequently associated with dietary habits, lifestyle factors, and behavioral stool withholding. Limited Indian data exist regarding the interaction between dietary pat [....] » Read More
Introduction: Gastrointestinal (GI) amyloidosis is a rare and frequently underrecognized manifestation of systemic amyloidosis. Its presentation is often nonspecific, particularly in elderly patients, leading to delayed diagnosis. Histologic confirmation with Congo red staining r [....] » Read More
Non-alcohol related fatty liver disease (NAFLD) is characterized by steatosis resulting from factors unrelated to excessive alcohol consumption. It frequently coexists with other metabolic disorders such as high cholesterol, obesity, and diabetes. The use of glucagon-like p [....] » Read More
Background: Functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome and functional dyspepsia, are commonly encountered in tertiary care settings and are often challenging to diagnose due to the absence of structural abnormalities. Artificial intellige [....] » Read More
AI is so inclusive that it stands to radically alter the employment landscape within medicine. Entire subspecialities will be cannibalized or fragmented into smaller entities. Physicians are both providers and venders of medical services. The services rendere [....] » Read More
This keynote examines the bidirectional gut-brain axis and its clinical relevance for gastroenterology practice, emphasizing that psychological and emotional states influence gastrointestinal symptoms through real, measurable physiology-and that GI symptoms can, in turn, shape mo [....] » Read More
The population in Israel is composed of diverse communities: Jews, Arabs, and immigrant groups from various countries, including communities from Yemen, Ethiopia, Morocco, the former Soviet Union, and a long-standing population. Numerous medical studies have examined specific [....] » Read More
Sickle cell disease (SCD) is a common inherited hematological disorder in Saudi Arabia, and hepatic involvement is an important but frequently underestimated component of its multisystem burden. This presentation reviews the spectrum of sickle cell liver disease (SCLD), highlight [....] » Read More
IL-17 family comprises six cytokines (IL-17A to IL-17F) and five receptors (IL-17RA to IL-17RE). IL-17RA acts as a common receptor subunit for several cytokines of the family. IL-17A, also known simply as IL-17, is a key pro-inflammatory cytokine that synergizes with TNF to ampli [....] » Read More
Background and objective: Neuropsychological outcomes, including fatigue, sleep disturbance, pain, cognitive impairment, delirium, and emotional symptoms, often occur concomitantly in patients with gastrointestinal cancers. In recent years, the microbiota–gut–brain ax [....] » Read More
Background and Objective: Gastrointestinal cancers present patients with high levels of uncertainty about physical symptoms, response to treatment, and the future of the disease. However, intolerance of uncertainty alone may not be sufficient to explain impaired future-imagining, [....] » Read More
Introduction: Crohn's disease is an inflammatory condition that affects the gastrointestinal (GI) system. This study aimed to determine the prevalence of upper gastrointestinal Crohn's disease (UGICD) and compare its features to non-UGICD types. Methods: We con [....] » Read More
A 67-year-old man presenting repeatedly with fever, diarrhoea, and progressive thoracic back pain following recent travel. Blood cultures confirmed Salmonella Java bacteraemia. Initial Computed Tomography (CT) was unremarkable. Due to persistent symptoms, repeat CT angiography de [....] » Read More
Background: Duodenal cobblestoning is typically associated with inflammatory conditions such as Crohn’s disease and rarely with intestinal lymphoma. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare, aggressive primary intestinal T-cell lymphoma [....] » Read More
The human gut microbiota constitutes a dynamic and densely populated ecosystem of over 1013 microorganisms whose compositional and functional integrity is essential for nutrient metabolism, epithelial barrier maintenance, immune regulation, and prevention of chronic non-comm [....] » Read More
The human gut microbiota constitutes a dynamic and densely populated ecosystem of over 1013 microorganisms whose compositional and functional integrity is essential for nutrient metabolism, epithelial barrier maintenance, immune regulation, and prevention of chronic non-comm [....] » Read More
Background: Laparoscopic D2 radical distal gastrectomy is a standard treatment for distal gastric cancer. Single-Incision Laparoscopic Surgery (SILS) offers potential advantages in cosmetic outcomes and recovery, but its technical complexity limits widespread adoption. We indepen [....] » Read More
Background and study aims: Endoscopic full-thickness resection (EFR) of gastric stromal tumors carries a high peritonitis risk. Our case report implied the preset pursestring procedure (PPP) could boost EFR speed and safety, but supporting clinical evidence is lacking, prompting [....] » Read More
Introduction: The most common bile duct disease in infants is biliary atresia (BA), which typically requires prompt surgical treatment for the best results, mostly pediatric liver transplantation. Globally, BA has an approximate frequency of 5 to 10 per 100,000 births. The study [....] » Read More
Background: Surgical site infection is one of the significant complications in post-operative patients. Method of preoperative hair removal is also considered as one of the risk factors for causing SSI. Razor blade, depilatory cream, clippers are used for hair removal. The o [....] » Read More
Liver related cancer and cirrhosis mortality rates have been reduced globally by the Hepatitis B vaccine however decay still happens. We aimed at determining the prevalence of breakthrough HBV infections (Exposure, Acute and chronic infections) and the prevalence of protective le [....] » Read More
Background: Operable locally advanced colon cancer has traditionally been managed with upfront surgical resection followed by adjuvant chemotherapy when indicated. Neoadjuvant chemotherapy (NAC) may provide tumor downstaging, improve the likelihood of complete resection, and trea [....] » Read More
Introduction: Pancreatic cancer currently the fourth leading cause of deaths and has one of the lowest 5-year related survival rates among all cancer sites 8% at all stages (Diener et al., 2017). Complete tumor resection is the only potentially curative option, so pancreaticoduod [....] » Read More
Bradycardia in the setting of abdominal pathology is an uncommon clinical finding. Cope’s sign - reflex bradycardia associated with acute cholecystitis (or cardio-biliary reflex) - is a rare but documented occurrence. Recognizing this atypical presentation is critical to av [....] » Read More
Objective The artificial intelligence(AI)-assisted detection reduces underdiagnosed or overlooked early esophageal cancers. We performed a meta-analysis to determine the diagnostic accuracy of AI used in white light endoscopy of patients with early esophageal cancer. Methods A s [....] » Read More
Background: Postoperative endoscopic assessment of the fundoplication wrap remains poorly standardized. Single-parameter classifications such as the Hill grade of the gastroesophageal flap valve, and Mittal-type descriptive systems, have been associated with substantial inter-obs [....] » Read More
Background: Cameron lesions — linear erosions or ulcerations at the diaphragmatic pinch within a hiatal hernia (HH) — are an under-recognized cause of occult gastrointestinal bleeding and chronic iron-deficiency anemia. They are classically associated with large HH, b [....] » Read More
Background: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder with multifactorial pathogenesis. Increasing evidence links IBS to gut microbiota alterations; however, findings remain heterogeneous and clinical translation is challenging. Aim: To e [....] » Read More
Title : How epigastric impedance would radically change gastric medicine
John Andrew Sutton, Invention City, United States
Epigastric impedance monitors measure liquid gastric emptying and motility non-invasively. Validated by several PhDs and 25 published papers it detected gastric delay whenever expected, plus the stimulant effect of prokinetics and reduced motility after opiates. Practical, due to [....] » Read More
Title : Role of Pregnancy (P) and breastfeeding on Gallstones (GS) related Acute Pancreatitis (AP)
Alberto Maringhini, La Maddalena Hospital, Italy
Parity is associated with GS only in younger mothers. High estrogen levels, mainly in the last trimester, increases cholesterol saturation of bile and high progesterone levels during all P reduce gallbladder contractility, both phenomenon may help sludge and GS precipitation.&nbs [....] » Read More
Title : Early and late evaluation of esophageal mucosectomy in surgical treatment of advanced esophageal achalasia
Jose Luis Braga De Aquino, Pontifical Catholic University of Campinas, Brazil
Endoscopic and/or laparoscopic myotomy has shown positive results in non-advanced esophageal achalasia due to the development of this surgical technique currently. For the most advanced stages of the disease, esophagectomy seems to be the most indicated procedure due to the invol [....] » Read More
Title : Iso-osmo-resistivity could explain mechanisms of digestion and absorption
John Andrew Sutton, Invention City, United States
Research into suitable meals for epigastric impedance found that lipid meals like ones containing double cream are highly resistant to electricity while proteins are conductive and carbohydrates are broadly neutral. The finding provoked the question: “Is this the basis by w [....] » Read More
Title : Early versus delayed enteral feeding in acute pancreatitis: A literature review
Radhika Patel, Croydon Health Trust, United Kingdom
Background: Acute pancreatitis is a common cause of hospital admission and is associated with significant morbidity and healthcare burden. Traditional management strategies often involved prolonged periods of nil by mouth; however, increasing evidence suggests that early entera [....] » Read More
Title : Intersecting haematologic, renal, and gastrointestinal disease: Hereditary spherocytosis with primary FSGS and ulcerative colitis: A case report
Aya Fares, Colchester Hospital, United Kingdom
Background: The coexistence of hereditary spherocytosis, focal segmental glomerulosclerosis (FSGS), and ulcerative colitis is exceedingly rare and poses significant diagnostic and therapeutic challenges. Case Presentation: This manuscript describes an exceptionally rare cli [....] » Read More
Title : Trends in compliance with the BSG acute upper gastrointestinal bleeding care bundle at a district general hospital: A four-cycle retrospective audit (2020-2025)
Moses G Ogundipe, University of Buckingham Medical School, United Kingdom
Introduction: Acute Upper Gastrointestinal Bleeding (AUGIB) is a common medical emergency with a 30-day mortality of up to 10%. The British Society of Gastroenterology (BSG) AUGIB consensus care bundle standardises management across six domains: Recognition, Resuscitation, R [....] » Read More
Title : Trends in compliance with the BSG acute upper gastrointestinal bleeding care bundle at a district general hospital: A four-cycle retrospective audit (2020-2025)
Shahd Elhakim, University of Buckingham Medical School, United Kingdom
Introduction: Acute Upper Gastrointestinal Bleeding (AUGIB) is a common medical emergency with a 30-day mortality of up to 10%. The British Society of Gastroenterology (BSG) AUGIB consensus care bundle standardises management across six domains: Recognition, Resuscitation, R [....] » Read More
Title : Immune checkpoint inhibitor-related cholangitis: A single-centre retrospective case series and management outcomes
Ahmed Elshafey, Leeds University Teaching Hospitals, United Kingdom
Background: Since immune checkpoint inhibitors (ICIs) have been introduced for over a decade, a massive improvement in cancer survival rate (median 7.8 to 19.0 months) has occurred but can precipitate immune-related adverse events across organ systems. Immune checkpoint inhibit [....] » Read More
Title : Pitfalls in colonoscopy: A rare endoscopic never event identified through histopathological discordance
Rajan Panacer, University Hospitals Birmingham, United Kingdom
Introduction: Colonoscopy is a routinely used diagnostic and therapeutic tool and is considered the gold standard investigation for assessment of colorectal pathology. Whilst colonoscopy can lead to rare but serious complications, incorrect vaginal intubation during these ar [....] » Read More
Title : Mimicking polycystic liver disease: A case report of innumerable cystic hepatic metastases from a pancreatic neuroendocrine tumour and diagnostic role of endoscopic ultrasound
Rida Abbasi, Manchester University NHS Foundation Trust, United Kingdom
Pancreatic neuroendocrine tumours (PNETs) are rare neoplasms, accounting for approximately 1–2% of all pancreatic malignancies. Their clinical and radiological presentation can be highly variable, particularly in non-functioning tumours. Cystic hepatic metastases are an unc [....] » Read More
Title : Early and late evaluation of palliative surgical treatment with isoperistaltic gastric tube associated with chemoradiation in advanced esophageal cancer
Jose Luis Braga De Aquino, Pontifical Catholic University of Campinas, Brazil
Although malignant neoplasms of the esophagus remain a very common disease, their diagnosis might often come late. This issue combined with excessive weight loss due to dysphagia and the association with cardiopulmonary diseases resulting from excessive tobacco use, makes patient [....] » Read More
Title : AI-supported autonomous ingestible micro-robotic endoscope with wired high-speed communication for total gastrointestinal exploration and therapy
Hidetoshi Ohta, Sapporo Orthopaedics and Cardiovascular Hospital, Japan
Background and Aims: Artificial intelligence and robotic technologies are rapidly advancing; however, their integration into gastrointestinal endoscopy remains limited and has not yet fully met clinical demands. We are developing a novel ingestible micro-robotic endoscope capable [....] » Read More
Title : Precision management of gastric LGIN: Development and validation of a risk scoring system to predict pathological upgrading
Yaoqian Yuan, The First Medical Center of Chinese People's Liberation Army General Hospital, China
Background: The discrepancy between endoscopic biopsy pathology and final resection pathology in gastric low-grade intraepithelial neoplasia (LGIN) poses a significant clinical challenge. A substantial proportion of LGIN cases are upgraded to high-grade intraepithelial neoplasia [....] » Read More
Title : Chronic hepatitis of trematode etiology: Innovative technologies of intraduodenal therapy and quantum-hydrogen liver regeneration
Ashot Khachatryan, International Network of Hydrogen Medicine Clinics, Armenia
Modern international hepatology focuses predominantly on the therapy of viral hepatitis, frequently ignoring concomitant pathologies that provoke, sustain, and exacerbate chronic liver inflammation. Our 30-year clinical experience proves that chronic parasitic infestations are a [....] » Read More
Title : Integrative medicine for disorders of gut-brain interaction: Evidence-based approaches in irritable bowel syndrome
Neha V Patel, UT Southwestern Medical Center, United States
Disorders of gut-brain interaction (DGBIs), including irritable bowel syndrome (IBS), are among the most prevalent gastrointestinal conditions and are characterized by complex interactions between the enteric nervous system, central nervous system, gut microbiome, immune pathways [....] » Read More
Title : Real world outcomes in fecal incontinence care: Effects of social determinants of health, hormonal therapy, dyssynergic defecation, and treatment engagement
Neha V Patel, UT Southwestern Medical Center, United States
Background & Aims: Fecal incontinence (FI) is a common and debilitating pelvic floor disorder that disproportionately affects women and frequently coexists with other anorectal dysfunctions. Although dyssynergic defecation (DD) is traditionally associated with constipation, i [....] » Read More
Title : Utilizing a 3D-printed laparoscopic Nissen fundoplication model to shorten a resident's learning curve
Muhammad Osama Wali Zada, Hangzhou Medical College, China
Laparoscopic Nissen fundoplication (LNF) requires extensive training for surgical proficiency, with significant early learning curve complications. A structured training protocol utilizing a 3D-printed anatomical model is described and designed to accelerate the acquisition of ad [....] » Read More
Title : EUS-guided colo-enteric anastomosis for complete malignant large bowel obstruction in a frail elderly patient: A rare minimally invasive salvage procedure
Mohammad Tabish, Felix Hospital Noida, India
Background: Complete malignant large bowel obstruction in frail elderly patients presents a major therapeutic challenge when conventional colonic stenting fails and surgery carries prohibitive risk. We report a rare case in which advanced endoscopic intervention was used as a lif [....] » Read More
Title : Vitamin D status in patients with irritable bowel syndrome: An audit in primary care
Abarna Sivarajah, Barts and the London Medical School, United Kingdom
Background: Irritable Bowel Syndrome is a common gastrointestinal disorder with its exact cause being unknown and multifactorial. The pathophysiology involves immune dysregulation and alterations in gut microbiota. Emerging evidence suggests that Vitamin D levels may impact gastr [....] » Read More
Title : Key indicators of esophageal cancer in Uzbekistan for the period 2000-2024
Abror Yusupbekov, National Oncology and Radiology Practice and Research Medical Center, Uzbekistan
Differences in the geographical distributions of esophageal cancer (EC) are associated with environmental influences and genetic risk factors. The inhabitants of the Republic of Uzbekistan are at high-risk for EC, however, detailed epidemiological data regarding the dynamics of E [....] » Read More