Title : Polymorphisms MMP9 gene are associated with peptic ulcer disease in men, and polymorphism MMP1 gene is disorder-associated in women
Abstract:
In this work, a comparative analysis of the matrix metalloproteinase (MMP) gene polymorphisms associations with peptic ulcer disease (PUD) in men and women was carried out. Material and methods. The study sample included 305 men (188 PUD patients, 117 control) and 441 women (211 PUD patients, 230 control). The 10 polymorphisms of MMP genes (rs1799750 MMP1; rs243865 MMP2; rs679620 MMP3; rs1940475 MMP8; rs3918242;rs3918249;rs17576;rs3787268; rs2250889;rs17577 of the MMP9 gene) were studied. The plink program was used to study the associations. Results. Differences in the nature of the genetic determination of PUD in men and women were revealed. In men with alleles C rs3918249 and G rs17576 of the MMP9 gene, the risk of PUD was increased (OR=1.61/pperm= 0.048 and OR=1.48-2.08/pperm≤0.042, respectively. In women, the 2G rs1799750 allele of the MMP1 gene correlated with a low risk of PUD (OR=0.74/pperm= 0.047). PUD-significant polymorphic loci have serious epigenetic effects (they determine the sensitivity of DNA to transcription factors, are located in the region of promoters/enhancers in the stomach and duodenum, are associated with gene expression in various parts of the digestive system). Conclusion. Polymorphisms rs3918249 and rs17576 of the MMP9 gene are associated with PUD in men, and rs1799750 of the MMP1 gene is associated with PUD in women.
