GASTRO 2024_ Event Postponement

This is to inform that due to some circumstances beyond the organizer control, “2nd Edition of International Conference on Gastroenterology” (Gastro 2024) during October 21-23, 2024 at Baltimore, MD, USA has been postponed. The updated dates and venue will be displayed shortly.

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2nd Edition of International Conference on Gastroenterology

October 21-23, 2024, Baltimore, Maryland, USA

October 21 -23, 2024 | Baltimore, MD, USA
Gastro 2023

Polymorphisms MMP9 gene are associated with peptic ulcer disease in men, and polymorphism MMP1 gene is disorder-associated in women

Speaker at GI Conferences - Mikhail Churnosov
Mikhail Churnosov
Belgorod State University, Russian Federation
Title : Polymorphisms MMP9 gene are associated with peptic ulcer disease in men, and polymorphism MMP1 gene is disorder-associated in women

Abstract:

In this work, a comparative analysis of the matrix metalloproteinase (MMP) gene polymorphisms associations with peptic ulcer disease (PUD) in men and women was carried out. Material and methods. The study sample included 305 men (188 PUD patients, 117 control) and 441 women (211 PUD patients, 230 control). The 10 polymorphisms of MMP genes (rs1799750 MMP1; rs243865 MMP2; rs679620 MMP3; rs1940475 MMP8; rs3918242;rs3918249;rs17576;rs3787268; rs2250889;rs17577 of the MMP9 gene) were studied. The plink program was used to study the associations. Results. Differences in the nature of the genetic determination of PUD in men and women were revealed. In men with alleles C rs3918249 and G rs17576 of the MMP9 gene, the risk of PUD was increased (OR=1.61/pperm= 0.048 and OR=1.48-2.08/pperm≤0.042, respectively. In women, the 2G rs1799750 allele of the MMP1 gene correlated with a low risk of PUD (OR=0.74/pperm= 0.047). PUD-significant polymorphic loci have serious epigenetic effects (they determine the sensitivity of DNA to transcription factors, are located in the region of promoters/enhancers in the stomach and duodenum, are associated with gene expression in various parts of the digestive system). Conclusion. Polymorphisms rs3918249 and rs17576 of the MMP9 gene are associated with PUD in men, and rs1799750 of the MMP1 gene is associated with PUD in women.

Biography:

Dr. Professor Mikhail Churnosov qualified as a doctor at Kursk State Medical University. He received the degree of Doctor of Medical Sciences in genetics in 1998 and the academic title of professor in 2000. Since 1998, he has been working as the head of the Department of Medical Biological Disciplines of the Medical Institute of the Belgorod State National Research University. About 50 candidates and doctors of sciences have been trained under his leadership. He has more than 150 scientific papers in the field of studying genetic factors of common diseases in the population of Central Russia (reproductive disorders, cancer, hypertension, etc.).

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