Title : Redefining gastrointestinal pathogenicity with crohn’s diseases
Abstract:
Crohn’s disease is an experiment in nature that has identified a new mechanism by which an exogenous organism, Mycobacterium Avium subspecies Paratuberculosis (MAP), can produce disease within the gastrointestinal tract. Once it was evident that disruption of the immune system’s Th 1 pro-inflammatory response could ameliorate the symptomology of individuals afflicted with Crohn’s disease, solving the enigma of its causation took a back seat to the rush to develop patentable drug therapy. Crohn’s disease became the poster-boy for autoimmune diseases despite its inability to induce anything more than a 40% temporary remission and to explain the epidemiological features that characterized Crohn’s disease. In 2015, the Hruska Postulate was introduced which has since been shown to be able to address every fact embedded in the natural history of disease as well as offer scientific proof. Crohn’s disease is an immune-mediated disease whose trigger mechanism is created by MAP infection of newborn infant in the absence of acquired immunity. Its translation into disease requires repeated and concentrated ingestion of MAP adulterated milk-based food.
The Hruska Postulate explains why Crohn’s disease is preventable, why dietary manipulation are one of the rare causes of permanent remissions, and why the permanent sequelae of disease are secondary to physician failure to treat sub -lamina propria infection by the gastrointestinal microbiota
Audience Take Away:
- The events that combine to produce Crohn’s disease
- Intergradation of this knowledge into current therapeutics
- How a global pandemic within industrialized nations can be defused
- Introduction into how an infectious disease can be transformed into an immune mediated disease
