GASTRO 2024_ Event Postponement

This is to inform that due to some circumstances beyond the organizer control, “2nd Edition of International Conference on Gastroenterology” (Gastro 2024) during October 21-23, 2024 at Baltimore, MD, USA has been postponed. The updated dates and venue will be displayed shortly.

Your registration can be transferred to the next edition, if you have already confirmed your participation at the event.

For further details, please contact us at gastroenterology@magnusconference.com or call + 1 (702) 988-2320.

HYBRID EVENT: You can participate in person at Baltimore, MD, USA or Virtually from your home or work.

2nd Edition of International Conference on Gastroenterology

October 21-23, 2024, Baltimore, Maryland, USA

October 21 -23, 2024 | Baltimore, MD, USA
Gastro 2023

The role of transforming growth factor-?1 signaling pathway during the process of angiogenesis induced by chronic stress in colorectal cancer

Speaker at Gastroenterology Conference - Zhang Jie
Zhang Jie
Chongqing Medical University, China
Title : The role of transforming growth factor-?1 signaling pathway during the process of angiogenesis induced by chronic stress in colorectal cancer

Abstract:

Chronic stress could induce stress-related hormone (SRH), including norepinephrine (NE). In this study, chronic restraint stress (CRS) was demonstrated to attenuate the efficacy of bevacizumab and promote tumor growth and angiogenesis in a colorectal tumor model. Propranolol, blocked this effect and inhibited the elevation of TGF-β1 caused by CRS or NE. Furthermore, we found that NE up-regulated HIF-1α expression, which was reversed by propranolol and Ly2157299 (the inhibitor of TGF-β receptor Type I kinase). Therefore, β-AR/TGF-β1 signaling/HIF-1α/VEGF was a signaling pathway involved in chronic stress-related tumor angiogenesis.

 Audience Take aways:

  • This study indicates that psychosocial stress could weaken the efficacy of anti-angiogenic therapy in colorectal cancer.
  • Propranolol blocked chronic stress-stimulated tumor growth and angiogenesis
  • Norepinephrine induced TGF-β1 and HIF-1α expression leading to VEGF secretion.
  • It also indicates that psychosocial stress might be a risk factor in cancer patients.

Biography:

Dr. Zhang studied oncology at the Sichuan University, China begin in 2010 and graduated as MD in 2016. He joined the research group of Prof. Gan Lu at the Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing up to now. He has published more than 10 research articles in SCI journals.

 

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