Title : Involvement of helicobacter pylori infection as a risk factor for cardiovascular diseases in cameroon myth or reality?
H.pylori infection is universally prevalent and constitutes a public health problem due
to its prevalence, cost, morbidity and mortality. This infection, although contraindicated, is
associated with risk factors for cardiovascular disease. During our study, we collected 1815
biopsies from 363 patients where we detected the presence of H pylori by histological tests.
5ml of blood from each patient was used to determine the lipid profile. The parameters height,
weight was taken in order to calculate the BMI. Blood pressure and heart rate were also
assessed for each patient. We recorded an overall prevalence of H pylori infection in our
study population of 65.4%. H pylori positive patients had a high total cholesterol
concentration and a high LDL cholesterol concentration with a p-value of 0.0004 and 0.0006
respectively. The univariate and multivariate analysis between Helicobacter pylori infection
and dyslipidaemia adjusted for potential confounding factors showed a significant association
between H pylori infection and total hypercholesterolaemia with a P value of 0.0002 and an
OR of 2.3324 (95% CI). However, a well elevated systolic blood pressure was noted although
less significant in H pylori positive patients as well as in patients with HDL
hypocholesterolemia with respective p values of 0.0841 and 0.4227. H pylori infection was
not associated with obesity and triglyceride levels.
H pylori infection would lead to dyslipidaemia which would eventually promote
arteriosclerosis, the starting point for cardiovascular disease.