Collagenous Colitis

Collagenous colitis is an inflammatory disorder of the large intestine (colon) characterized by chronic inflammation of the colon wall’s innermost layer, the mucosa. It is caused by a buildup of collagen in the colon wall, which leads to thickening and scarring of the tissue. Collagenous colitis is different from ulcerative colitis, which is also an inflammatory disorder of the colon, but is characterized by ulcers in the mucosa. The exact cause of collagenous colitis is unknown, but it is thought to be linked to an abnormal immune response, in which the body’s own immune system mistakenly attacks the colon. It may also be linked to the use of certain medications, such as antibiotics. The primary symptom of collagenous colitis is watery diarrhea, which may be accompanied by abdominal pain, cramping, bloating, and weight loss. Other symptoms may include fatigue, fever, loss of appetite, and vomiting. In some cases, blood or mucus may be present in the stool. Diagnosis of collagenous colitis is made through a combination of tests, including a physical examination, blood tests, and a colonoscopy. During a colonoscopy, a physician will examine the inside of the colon and take a tissue sample for biopsy. The biopsy will be examined for signs of inflammation and collagen buildup. Treatment of collagenous colitis typically involves medications to reduce inflammation and control symptoms, such as antibiotics and corticosteroids. In severe cases, surgery may be necessary to remove the affected area of the colon. Collagenous colitis is a serious condition, but it is usually manageable with proper treatment. It is important to follow your doctor’s instructions and take all medications as prescribed. Eating a healthy diet and getting regular exercise can also help to reduce symptoms and prevent flares.