Hepatitis is an inflammation of the liver caused by a virus, toxic substances, or other agents. It is a major global health problem and a leading cause of death worldwide. There are five types of hepatitis: A, B, C, D, and E. Each type is caused by a different virus and has different symptoms and treatments. Hepatitis A is the most common type and is spread through contact with fecal matter, contaminated food or water, or close contact with an infected person. Symptoms can include fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, jaundice, and dark urine. Vaccines are available to prevent hepatitis A, and most cases of acute hepatitis A are mild and resolve without treatment. Hepatitis B is spread through contact with contaminated blood or body fluids, such as through sexual contact or sharing needles. Symptoms can include fever, nausea, vomiting, abdominal pain, jaundice, dark urine, and fatigue. There is a vaccine available to prevent hepatitis B, and most cases of acute hepatitis B can be treated with antiviral medications. Hepatitis C is spread through contact with contaminated blood, such as through sharing needles or sexual contact.