Mucosa is a term used to describe the innermost layer of tissue that lines the body's internal cavities, such as the nose, trachea, GI tract, and bladder. It is composed of several layers of cells and is made up of a combination of epithelial cells, connective tissues, and specialized secretory cells. The mucosal layer serves several important functions, including protection from microorganisms and other foreign particles, secretion of mucus and other fluids, and absorption of nutrients. The mucosa also plays an important role in the immune system by secreting immunoglobulins and producing inflammatory mediators. The epithelial layer of the mucosa is composed of columnar epithelial cells, which are tightly packed and form an effective barrier against microorganisms and other foreign particles. The secretory cells of the mucosa produce mucus, which is composed of glycoproteins and provides a protective coating. This mucus helps to lubricate the mucosal layer and trap foreign particles and microorganisms. In addition, the mucosa contains specialized cells called goblet cells, which secrete mucins, a group of glycoproteins that form the gel-like consistency of mucus.