Neoplasm of the liver is an abnormal growth or tumor that is found in the liver. It can be benign (non-cancerous) or malignant (cancerous). Neoplasms of the liver can be caused by a variety of factors, including genetic predisposition, environmental exposures, and lifestyle habits. The most common types of neoplasms of the liver are hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hemangioma. HCC is the most common primary liver cancer, and is often the result of chronic hepatitis B or C infections, alcohol abuse, non-alcoholic fatty liver disease, and cirrhosis. CCA is the most common bile duct cancer, and is often caused by bile duct obstruction, chronic inflammation, and cirrhosis. Hemangiomas are the most common benign liver tumors. They are usually asymptomatic, but can cause complications if they are large or located near major blood vessels. Diagnosis of neoplasms of the liver involves imaging tests such as computed tomography (CT) or magnetic resonance imaging (MRI) scans, as well as blood tests to check for abnormal levels of tumor markers. Treatment depends on the type, size, and location of the tumor, and may include surgery, chemotherapy, radiation therapy, or targeted therapy. Neoplasms of the liver can be serious and life-threatening. It is important for people with a family history of liver cancer to be aware of the risks and seek medical advice if they experience any symptoms. Early detection and treatment can improve the chances of successful treatment and improve the outlook for those affected.