Radiation therapy is a type of cancer treatment used to eliminate cancer cells from the body. It involves the use of high-energy particles or waves, such as x-rays, gamma rays, and protons, to kill cancer cells. Radiation therapy is often used to treat gastrointestinal (GI) diseases, such as colon cancer, rectal cancer, and esophageal cancer. Radiation therapy for GI diseases is typically used in conjunction with other treatments, such as chemotherapy, surgery, or immunotherapy. It is used to destroy cancerous cells that have spread beyond the site of the original tumor. It can also be used to shrink the tumor prior to surgery or to relieve symptoms, such as pain or blockage, caused by the tumor. Radiation therapy can be delivered in two ways: external beam radiation or internal radiation. External beam radiation, which is the most common type of radiation therapy, is delivered from a machine outside of the body. This type of radiation is usually used to treat tumors that are too large or too close to vital organs to be treated with surgery. Internal radiation, also known as brachytherapy, involves the placement of a radioactive source inside the body, near the tumor. This type of radiation is often used in combination with external beam radiation to treat tumors located in difficult-to-reach areas. The side effects of radiation therapy for GI diseases vary depending on the type of therapy and the area of the body being treated. Common side effects of radiation therapy for GI diseases include nausea, vomiting, diarrhoea, and fatigue. In some cases, radiation therapy can also cause skin irritation and changes in the gastrointestinal tract, including bleeding, narrowing, and ulceration. Radiation therapy can be a powerful and effective treatment for GI diseases. However, it is important to discuss the potential risks and side effects with your doctor before starting treatment.