Colorectal cancer remains a leading cause of cancer-related mortality, yet it is largely preventable through effective screening and early intervention. Advances in screening modalities, including high-quality colonoscopy and non-invasive testing, have improved early detection rates. Polyp detection, accurate characterization, and complete resection are essential components of cancer prevention. Quality metrics such as adenoma detection rate and complete excision are closely linked to long-term outcomes. Endoscopic resection techniques continue to evolve, allowing safe removal of complex and large lesions. Risk-based surveillance strategies help balance prevention with resource efficiency. This topic highlights best practices in colorectal cancer screening, advances in polyp management, and strategies to optimize prevention at the population level.