Pancreatobiliary interventions play a critical role in the diagnosis and treatment of complex pancreatic and biliary diseases. Endoscopic and minimally invasive techniques have transformed patient care by reducing the need for open surgery. These interventions are essential for managing biliary obstruction, pancreatic duct disorders, and complications of pancreatitis. Advances in imaging guidance, device technology, and procedural safety have expanded therapeutic options. This topic focuses on innovations in pancreatobiliary interventions, clinical indications, and outcomes, highlighting the importance of expertise and multidisciplinary collaboration.