Liver Cancer & Advanced Hepatobiliary Oncology

Primary liver cancer and advanced hepatobiliary malignancies represent a growing global health challenge, driven by chronic liver disease, viral hepatitis, and metabolic disorders. Early detection remains difficult, and many patients present with advanced disease. Advances in imaging, molecular profiling, and staging systems have improved diagnostic accuracy and treatment planning. Therapeutic options now include locoregional therapies, systemic targeted agents, immunotherapy, and combination approaches. Multidisciplinary care involving hepatology, oncology, surgery, and interventional radiology is essential for optimal management. Ongoing research focuses on identifying predictive biomarkers, overcoming treatment resistance, and improving survival in advanced disease. This topic explores evolving strategies in hepatobiliary oncology, emphasizing precision medicine and integrated care models.