Immune-mediated and eosinophilic gastrointestinal disorders are increasingly recognized as important causes of chronic GI symptoms across all age groups. These conditions arise from dysregulated immune responses involving eosinophils, mast cells, and cytokine-mediated inflammation, often without overt structural abnormalities. Patients may present with abdominal pain, dysphagia, diarrhea, weight loss, or malnutrition. Advances in endoscopic techniques, histopathology, and molecular profiling have improved diagnostic accuracy. Management strategies include dietary interventions, pharmacologic immunomodulation, and emerging biologic therapies targeting specific inflammatory pathways. This topic highlights evolving insights into disease mechanisms, diagnostic challenges, and novel treatment approaches aimed at reducing inflammation and improving patient quality of life.
Title : Gut mucosal immunity and inflammatory bowel disease
Youcun Qian, University of Chinese Academy of Sciences, China
Title : Early and late evaluation of esophageal mucosectomy in surgical treatment of advanced esophageal achalasia
Jose Luis Braga De Aquino, Pontifical Catholic University of Campinas, Brazil
Title : The efficacy of fermented foods as an adjunct therapy in ulcerative colitis - a literature review
Jack D Doorly, Alfred Health, Australia
Title : Professional dining and health
Yaffa Machnes, Bar-Ilan University, Israel
Title : How epigastric impedance would radically change gastric medicine
John Andrew Sutton, Invention City, United States
Title : Differentiating simple and aggressive phenotypes of metabolic dysfunction-associated steatotic liver disease utilizing bioelectrical impedance-derived metabolic age gap
Yury Marakhouski, Belarusian State Medical University, Belarus