Immune-Mediated & Eosinophilic GI Disorders

Immune-mediated and eosinophilic gastrointestinal disorders are increasingly recognized as important causes of chronic GI symptoms across all age groups. These conditions arise from dysregulated immune responses involving eosinophils, mast cells, and cytokine-mediated inflammation, often without overt structural abnormalities. Patients may present with abdominal pain, dysphagia, diarrhea, weight loss, or malnutrition. Advances in endoscopic techniques, histopathology, and molecular profiling have improved diagnostic accuracy. Management strategies include dietary interventions, pharmacologic immunomodulation, and emerging biologic therapies targeting specific inflammatory pathways. This topic highlights evolving insights into disease mechanisms, diagnostic challenges, and novel treatment approaches aimed at reducing inflammation and improving patient quality of life.