Pediatric gastroenterology and hepatology address gastrointestinal and liver diseases occurring from infancy through adolescence, with unique diagnostic and therapeutic challenges. Many conditions—including congenital liver diseases, inflammatory bowel disease, functional GI disorders, and nutritional deficiencies—present differently in children compared to adults. Early diagnosis is critical to prevent long-term complications affecting growth, development, and quality of life. Advances in pediatric endoscopy, imaging, genetic testing, and non-invasive biomarkers have improved diagnostic accuracy. Treatment strategies increasingly emphasize individualized care, family involvement, and transition planning to adult services. This topic highlights current advances in pediatric GI and liver disease management, emerging therapies, and long-term outcome optimization in young patients.