Acalculous Gallbladder Disease (AGD) is a condition where the gallbladder becomes inflamed and swollen without the presence of gallstones. AGD can be caused by a number of different factors, such as viral or bacterial infections, medications, trauma, or underlying medical conditions. It can also be caused by a lack of bile flow through the gallbladder, which can occur after certain surgeries or in cases of obesity. Symptoms of AGD may include abdominal pain and tenderness, nausea, vomiting, fever, and jaundice. Other symptoms may include loss of appetite, bloating, and weight loss. Diagnosis of AGD may involve abdominal ultrasound, CT scan, or MRI. Blood tests may also be ordered to check for inflammation, infection, or other factors that could be causing the condition. Treatment for AGD may involve antibiotics, anti-inflammatory medications, or medications to reduce pain and nausea. In some cases, surgery may be necessary to remove the gallbladder or drain any fluid buildup. Additionally, lifestyle changes, such as a healthy diet and regular exercise, can be beneficial.