Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer that begins in the cells of the pancreas. The pancreas is an organ located behind the stomach that produces hormones and enzymes that help with digestion. PDAC is the most common type of pancreatic cancer, accounting for about 95% of all cases. It usually affects older adults and is more common in men than women. PDAC typically starts in the ducts of the pancreas, but can also begin in the cells that produce digestive enzymes. As the cancer grows, it can spread to nearby organs and lymph nodes. Symptoms of PDAC can include abdominal pain, jaundice, unexplained weight loss, and blood clots. Diagnosis is typically done with imaging tests, endoscopic ultrasound, and a biopsy of the tumor. Treatment options for PDAC include surgery to remove the tumor, chemotherapy, radiation therapy, and targeted therapy. Surgery is the most effective treatment option, but it is not always possible due to the location of the tumor or other factors. Chemotherapy and radiation therapy can be used to shrink the tumor before or after surgery, or as a standalone treatment.