Pancreatic fibrosis is a condition in which the pancreas becomes scarred and stiff due to inflammation. This can lead to a number of complications, including diabetes, chronic pancreatitis, and pancreatic cancer. The cause of pancreatic fibrosis is not always known, but it is thought to be due to a combination of genetic and environmental factors. For example, chronic alcohol abuse and smoking can increase the risk of developing pancreatic fibrosis. It can also be caused by an autoimmune disorder, such as sclerosing cholangitis or celiac disease. In some cases, it may be the result of a bacterial or viral infection. Pancreatic fibrosis can cause a number of symptoms, including abdominal pain, nausea, vomiting, weight loss, and jaundice. It can also cause the pancreas to become enlarged, which can lead to a decrease in the production of important hormones and enzymes. In some cases, it can also cause blockages in the bile ducts, leading to inflammation of the pancreas and impaired digestion. Treatment for pancreatic fibrosis depends on the underlying cause. In some cases, lifestyle changes such as quitting smoking or abstaining from alcohol may be helpful.