Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) is a chronic, progressive autoimmune disease that affects the bile ducts of the liver. It is caused by an autoimmune process, in which the body’s immune system mistakenly attacks and destroys the bile ducts, causing damage to the liver that results in inflammation and scarring. In the early stages of the disease, the liver has difficulty getting rid of bile, which can lead to a buildup of bile acids in the bloodstream. This buildup of bile acids can result in itching, fatigue, and jaundice. As the disease progresses, scarring of the liver can occur, leading to cirrhosis and liver failure. Treatment for PBC typically involves medications such as ursodeoxycholic acid (UDCA) and corticosteroids to reduce inflammation and slow the progression of the disease. In addition, lifestyle modifications such as avoiding alcohol and maintaining a healthy weight are recommended. In some cases, a liver transplant may be necessary to restore liver function. PBC can be difficult to diagnose because its symptoms can be similar to other liver diseases. Diagnosis usually involves blood tests, imaging tests, and a biopsy of the liver. Early diagnosis and treatment can help slow the progression of the disease and reduce the risk of complications. It is important to talk to your doctor if you experience any of the symptoms of PBC, as early diagnosis and treatment can help slow the progression of the disease.