The upper gastrointestinal (GI) tract includes the esophagus, stomach, and duodenum. Disorders of the upper GI tract can be caused by a variety of factors, such as viral infections, bacteria, inflammation, or genetic conditions. Treatment for upper GI tract disorders depends on the underlying cause and may include medications, lifestyle changes, and surgery. Medications are often used to treat upper GI tract disorders. Anti-inflammatory drugs can reduce inflammation in the gastrointestinal tract. Antibiotics may be prescribed to treat bacterial infections. Antacids can be used to neutralize stomach acid, while proton pump inhibitors can reduce the amount of acid produced in the stomach. In some cases, lifestyle changes may be recommended to treat upper GI tract disorders. Eating smaller meals more frequently can reduce the risk of acid reflux. Quitting smoking can also help reduce symptoms. Avoiding foods and beverages that are high in acid and fat may also help. In more serious cases, surgery may be recommended. Surgery can be used to correct structural problems in the upper GI tract, such as a hiatal hernia. Surgery can also be used to remove tumors or infected tissue.